Olivier BIROT

Associate Professor

Locations / Contact Info:

Keele Campus
Phone: 416 736 2100 Ext. 44043

Locations / Contact Info:

353 Norman Bethune College - BC
Keele Campus
Phone: 416 736 2100 Ext. 44043

Email address(es):


Faculty & School/Dept.

Faculty of Health - School of Kinesiology & Health Science


Postdoctoral Fellow - 2006
Karolinska Institutet
Stockholm, Sweden

PhD - Physiology - 2003
Université Claude Bernard
Lyon, France

MSc (DEA) - Physiology of Extreme Environments - 1998
Université Claude Bernard
Lyon, France

Selected Publications

Amouzou C, Breuker C, Fabre O, Bourret A, Lambert K, Birot O, Fédou C, Dupuy AM, Cristol JP, Sutra T, Molinari N, Maimoun L, Mariano-Goulart D, Galtier F, Avignon A, Stanke-Labesque F, Mercier J, Sultan A, Bisbal C. Skeletal muscle insulin resistance and absence of inflammation characterize insulin-resistance grade I obese women. PLoS One, 11(4), 2016


Aiken J, Roudier E, Ciccone J, Drouin G, Stromberg A, Vojnovic J, Olfert IM, Haas T, Gustafsson T, Grenier G, Birot O. Phosphorylation of murine double minute-2 on Ser166 is downstream of VEGF-A in exercised skeletal muscle and regulates primary endothelial cell migration and FoxO gene expression. FASEB J. 2016 Mar;30(3):1120-34. doi: 10.1096/fj.15-276964. Epub 2015 Nov 17.


Roudier E, Aiken J, Slopack Dara, Gouzi F, Mercier J, Haas TL, Gustaffson T, Hayot M, Birot, O. Novel perspective:  Exercise training stimulus triggers the expression of the oncoprotein Human Double Minute-2 in human skeletal muscle. Physiological Reports 1, 2014


Gouzi F, Prefaut C, Abdellaoui A, Roudier E, de Rigal P, Molinari N, Laoudj-Chenivesse D, Mercier J, Birot O, Hayot M. Blunted muscle angiogenic training-response in COPD patients versus sedentary controls. European Respiratory Journal 41:806-14, 2013 



Roudier E, Forn P, Perry ME, Birot O. Murine Double Minute-2 is required for capillary maintenance and exercise-induced angiogenesis in skeletal muscle. FASEB Journal 26:4530-4539, 2012 



Roudier E, Gineste C, Wazna A, Dehghan K, Desplanches D, Birot O. Angio-adaptation in unloaded skeletal muscle: New insights into an early and muscle-specific dynamic process. Journal of Physiology (London) 588: 4579-4591, 2010


Holmgren L, Ambrosino E, Birot O, Tullus C, Veitonmäkii N, Carlson L-M, Forni G and Kiessling R. A DNA vaccine targeting the angiostatin receptor angiomotin inhibits angiogenesis and suppresses tumor growth. Proc. Natl. Acad. Sci. USA 103: 9208-13, 2006


Karolinska Institutet (Sweden)
Co-investigator on various projets


Currently available to supervise graduate students: Yes

Currently taking on work-study students, Graduate Assistants or Volunteers: Yes

Available to supervise undergraduate thesis projects: Yes

Current Research

Cellular and molecular mechanisms regulating muscle angio-adaptation under physio- and pathological conditions.