David A Hood

Professor

NSERC Tier 1 Canada Research Chair in Cell Physiology

Locations / Contact Info:

302A Farquharson Life Sciences - FARQ
Keele Campus
Phone: 416 736 2100 Ext. 66640

Locations / Contact Info:

302 Farquharson Life Sciences - FARQ
Keele Campus
Phone: 416 736 2100 Ext. 77832

Email address(es):

dhood@yorku.ca

Web site(s):

Hood Lab Website
Muscle Health Research Centre Website

Faculty & School/Dept.

Faculty of Health - School of Kinesiology & Health Science

Degrees

Ph.D Physiology - 1986
State University of New York

B.A. Physical & Health - 1979
Queen's University

M.Sc Physical Education - 1981
Dalhousie University

B.P.H.Education - 1979
Queen's University

Selected Publications

Papers in refereed journals  



Erlich, A. T. and D. A. Hood. Mitophagy regulation in skeletal muscle: Effect of endurance exercise and age. Journal of Science in Sport and Exercise. Accepted September 25, 2019



Oliveira, A. N. and D. A. Hood. Exercise is mitochondrial medicine for muscle. Sports Medicine and Health Science. 1:000-000, 2019



Memme, J. M., A. T Erlich, G. Phukan, and D. A. Hood. Exercise and mitochondrial health.  J. Physiol. (Lond.) in press, 2019



M. Triolo, and D. A. Hood Mitochondrial breakdown in skeletal muscle and the emerging role

of lysosomes. Arch. Biochem. Biophys. 661:66-73, 2019.



Kim, Y., M. Triolo, A. T Erlich, and D. A. Hood. Regulation of autophagic and mitophagic flux during chronic contractile activity-induced muscle adaptations. Pfluger’s Arch. 471:431-440, 2019.



Hood, D.A., J.M. Memme, A.N. Oliveira and M. Triolo. Maintenance of skeletal muscle mitochondria in health, exercise, and aging. Ann. Rev. Physiol. 81:19-41, 2019.



Beyfuss, K., A. T Erlich, M. Triolo and D. A. Hood. The Role of p53 in Determining Mitochondrial Adaptations to Endurance Training in Skeletal Muscle.  Sci. Reports. 8:14710, 2018.



Oliveira, A.N., and D.A. Hood. Effect of Tim23 Knockdown in vivo on Mitochondrial Protein Import and Retrograde Signaling to the UPRmt in Muscle. Am J Physiol Cell Physiol. https://doi.org/10.1152/ajpcell.00275.2017,2018



Chen, C.C.W., A. T. Erlich, M. J. Crilly and D. A. Hood. Parkin is required for exercise-induced mitophagy in muscle: impact of aging. Am. J. Physiol. (Endocrin. Metab.) 315:E404-E415, 2018.



Carter, H.N., Y. Kim, A. T. Erlich, D. Zarrin-Khat and D. A. Hood. Autophagy and mitophagy flux in young and aged skeletal muscle following chronic contractile activity. J. Physiol. (Lond.) 596:3567-3584, 2018.



Chen C.C.W., A.T. Erlich and D.A. Hood. Role of Parkin and endurance training on mitochondrial turnover in skeletal muscle. Skelet. Muscle 8:10, 2018.



Carter, H.N., M. Pauly, L.D. Tryon and D. A. Hood. Effect of contractile activity on PGC-1α transcription in young and aged skeletal muscle. J. Appl. Physiol. 124:1605-1615, 2018.



Parousis, A., H. N. Carter, C. Tran, A. T. Erlich, Z. S. Mesbah-Moosavi, M. Pauly and D.A. Hood.   Contractile activity attenuates autophagy suppression and reverses mitochondrial defects in skeletal muscle cells. Autophagy, 4:1-12, 2018.



Kim, Y., J. M. Memme and D.A. Hood. Application of chronic stimulation to study contractile  activity-induced rat skeletal muscle phenotypic adaptations. J. Vis. Exp., e56827, 2018.



Beyfuss, K and D.A. Hood. A systematic review of p53 regulation of oxidative stress in skeletal muscle. Redox Report: https://doi.org/10.1080/13510002.2017.1416773, 2018.



Erlich A.T., D.M. Brownlee, K. Beyfuss and D.A. Hood. Exercise induces TFEB expression and activity in skeletal muscle in a PGC-1α-dependent manner. Am J Physiol Cell Physiol. 314: C62-C72, 2018. An image from this paper was chosen as the "Image of the week" on AJP-Cell Physiology Social Media (Oct 20, 2017).



Kim, Y, M. Triolo and D.A. Hood. Impact of Aging and Exercise on Mitochondrial Quality Control in Skeletal Muscle. Oxid Med Cell Longev. 2017:3165396, 2017.



Kim, Y and D.A.Hood. Regulation of the autophagy system during chronic contractile activity-induced muscle adaptations.Physiol Rep. 5(14):e13307, 2017.



Mesbah Moosavi Z.S. and D.A. Hood. The unfolded protein response in relation to mitochondrial biogenesis in skeletal muscle cells. Am. J. Physiol. Cell Physiol. 312:C583-C594, 2017. An image from this paper was chosen as the "Image of the week" on AJP-Cell Physiology Social Media.



Hornberger T.A., H.N. Carter, D.A. Hood, V.C. Figueiredo, E.E. Dupont-Versteegden, C.A. Peterson, J.J. McCarthy, D.M. Camera, J.A. Hawley, T. Chaillou, A.J. Cheng, G.A. Nader, R.C. Wust, R.H. Houtkooper. Commentaries on Viewpoint: The rigorous study of exercise adaptations: Why mRNA might not be enough. J. Appl. Physiol. 121:597-600, 2016.



Crilly, M.J., L.D. Tryon, A.T. Erlich and D.A. Hood. The role of Nrf2 in skeletal muscle contractile and mitochondrial function. J. Appl. Physiol. 121(3):730-40, 2016.



Hood, D.A., L.D. Tryon, H.N. Carter, Y. Kim and C.C.W. Chen. Unraveling the mechanisms regulating muscle mitochondrial biogenesis. Biochem. J. 473(15):2295-314, 2016.



Erlich, A.T., L.D. Tryon, M.J. Crilly, J. M. Memme, Z. S. Mesbah Moosavi, A.N. Oliveira, K. Beyfuss and D.A. Hood. Function of specialized regulatory proteins and signaling pathways in exercise-induced muscle mitochondrial biogenesis.  Integr. Med. Res. 5(3):187-197, 2016.



Memme, J., A. Oliveira and D.A. Hood.  The chronology of UPR activation in skeletal muscle adaptations to chronic contractile activity.  Am. J. Physiol. Cell Physiol. 310: C1024-C1036, 2016.



Vainshtein, A. and D.A. Hood. The regulation of autophagy during exercise in skeletal muscle. J. Appl. Physiol. 120: 664-673, 2016.



Hood, D.A., L.D. Tryon, A. Vainshtein, J. Memme, C. Chen, M. Pauly, M.J. Crilly and H. Carter, Exercise and the Regulation of Mitochondrial Turnover. In: Claude Bouchard (Ed.), Progress in Molecular Biology and Translational Science, 135: 99-127, 2015.



Tryon, L.D., M.J. Crilly and D.A. Hood.  Effect of denervation on the regulation of mitochondrial transcription factor A expression in skeletal muscle. Am. J. Physiol. Cell Physiol. 309: C228-38, 2015.



Collu-Marchese, M., M. Shuen, M. Pauly, A. Saleem and D.A. Hood. The regulation of mitochondrial transcription factor A (Tfam) expression during skeletal muscle cell differentiation. Bioscience Reports 35: e00221, DOI: 10.1042/BSR20150073, 2015.  



Carter, H.N., C.C.W. Chen and D.A. Hood. Mitochondria, Muscle Health and Exercise with Advancing Age.  Physiology 30:208-223, 2015.



Vainshtein, A., E.M. Desjardins, A. Armani, M. Sandri, and D.A. Hood. PGC-1α modulates denervation-induced mitophagy in skeletal muscle. Skeletal Muscle 5:9, 2015.



Vainshtein, A., L.D. Tryon, M. Pauly, and D.A. Hood. The role of PGC-1α during acute exercise-induced autophagy and mitophagy in skeletal muscle.  Am. J. Physiol. Cell Physiol. 308:C710-C719, 2015.



 


Affiliations

Muscle Health Research Centre, Faculty of Health, York University
Director

Awards

York University Faculty of Health Established Career Research Award - 2009

Canadian Society for Exercise Physiology (CSEP) Honour Award - 2010

Distinguished Visiting Professor, Heart & Stroke / Richard Lewar Centre of Excellence in Cardiovascular Research - 2013

Peter A. Rechnitzer Lecturer, Centre for Physical Activity and Aging, Western University - 2013

York University Faculty of Health Established Career Research Award - 2013

Adam Barsky Lectureship on Mitochondrial Diseases, Hospital for Sick Children - 2014

Canadian Society for Exercise Physiology (CSEP) John R. Sutton Lecturer - 2015

Supervision

Currently available to supervise graduate students: Yes

Currently taking on work-study students, Graduate Assistants or Volunteers: Yes

Available to supervise undergraduate thesis projects: Yes

Current Research

Skeletal muscle biochemistry and molecular biology; mitochondrial turnover adaptations in muscle subject to chronic exercise, disuse or aging, including mechanisms of mitochondrial protein import and nuclear gene expression and mitophagy.

Research Projects

Mitochondria in Health and disease
Role: Principal Investigator
Amount funded: $1,400,000
Year Funded: 2017
Duration: 7
Funded by: Canada Research Chairs

Mitochondrial and lysosomal biogenesis in aging muscle: effect of exercise
Role: Principal Investigator
Amount funded: $740,000
Year Funded: 2018
Duration: 5
Funded by: Canadian Institutes of Health Research

Mitochondrial biogenesis in contracting muscle
Role: Principal Investigator
Amount funded: $325,000
Year Funded: 2016
Duration: 5
Funded by: Natural Sciences and Engineering Research Council

Curriculum Vitae (C.V. file):

CV of David A Hood