Christine Till

Associate Professor

Locations / Contact Info:

125 BSB
Keele Campus
Phone: 416 736 2100 Ext. 20776

Email address(es):

ctill@yorku.ca

Web site(s):

http://www.yorku.ca/ctill

Faculty & School/Dept.

Faculty of Health - Department of Psychology

Degrees

MA - 2000
University of Toronto
Toronto

PhD - 2004
University of Toronto
Toronto

Biography

Dr. Till received her B.Sc. (1997) from the University of Waterloo, Ontario. From there she moved to Toronto where she attended the University of Toronto to complete her Masters (2000) and PhD (2004) in Psychology. She then accepted a post-doctoral position at the Toronto Rehabilitation Institute where she completed her clinical training in neuropsychology (2006). She is a registered psychologist with an expertise in neuropsychology in both children and adults. Dr. Till is currently an Associate Professor in the Clinical Developmental Area through the Faculty of Health at York University. She is also appointed as an Adjunct Scientist of the Neurosciences and Mental Health Research Program at The Hospital for Sick Children.

Selected Publications

1.  Amato MP, Krupp LB, Charvet LE, Penner I-K, Till C. Pediatric multiple sclerosis: Cognition and mood. Neurology, in press.


2.  Akbar N, Giorgio A, Till C, Sled JG, Doesburg SM, De Stefano N, Banwell B.  (2016). Alterations in functional and anatomical connectivity in pediatric-onset multiple sclerosis, PLOS ONE 11(1): e0145906.


3.  Akbar N, Till C, Sled JG, Binns MA, Doesburg SM, Aubert-Broche B, Collins L, Araujo D, Narayanan S, Lysenko M, Banwell B.  (2015). Altered resting-state functional connectivity in pediatric-onset MS and relations to structural damage and cognition,  Multiple Sclerosis Journal, published online Sept 11, 2015 before print


4.  Akbar N, Banwell B, Sled JG, Binns MA, Doesburg SM, Rypma B, Lysenko M, Till C. (2015).  Brain activation patterns and cognitive processing speed in patients with pediatric-onset multiple sclerosis.  Journal of Clinical and Experimental Neuropsychology, 38(4):393-403.


5.  Weier W, Till C, Yeh EA, Fonov V, Arnold DL, Banwell B, Collins L. (2015) Contribution of the cerebellum to cognitive performance in children and adolescents with multiple sclerosis.  Multiple Sclerosis Journal, published online July 22, 2015 before print.


6.  Malin, A. & Till C. (2015). Exposure to Fluoridated Water and Attention Deficit Hyperactivity Disorder prevalence among children and adolescents in the United States:  An ecological association.  Environmental Health,14(17): 1-10.


7.  Aubert-Broche B, Fonov V, Narayanan S, Arnold DL, Araujo D, Fetco D, Till C, Sled JG, Banwell B, Collins DL.  (2014) Onset of multiple sclerosis in childhood and adolescence leads to failure of age-expected brain growth, Neurology,83(23): 2140-2146.


8.  Hosseini B, Flora DB, Banwell BL, Till C. (2014)  Age of onset as a moderator of cognitive decline in pediatric-onset multiple sclerosis.  Journal of International Neuropsychological Society, 20, 1-9.


9.  Todorow M, DeSouza J, Banwell B, Till C.  (2014)  Interhemispheric cooperation in a global-local visual processing task in pediatric multiple sclerosis, Journal of Clinical and Experimental Neuropsychology, 36(2): 111 - 126, 2014


10.   Till CRacine N, Araujo D, Narayanan S, Collins L, Aubert-Broche B, Arnold DL, Banwell B. (2013) Changes in cognitive performance over a one-year period in children and adolescents with multiple sclerosis, Neuropsychology, 27(2), 210-219.


11.   Marin S, Banwell B, Till C. (2013) Serial neuropsychological assessment over 10 years in four pediatric-onset multiple sclerosis patients, Journal of Child Neurology, 28 (12) : 1577 - 1586.


12.   Kuni B, Banwell B, Till C. (2012) Cognitive and behavioral outcomes in individuals with a history of acute disseminated encephalomyelitis (ADEM). Developmental Neuropsychology, 37(8), 1-15.


13.   Till C, Ho C, Dudani A, Ghassemi, R, Narayanan S, Arnold DL, Sled JG, Banwell B. (2012)  Magnetic resonance imaging predictors of executive functioning in patients with pediatric-onset multiple sclerosis.   Archives of Clinical Neuropsychology, 27: 1-15.


14.   Till C, Udler E, Ghassemi R, Narayanan R, Arnold DL, Banwell B.  (2012)  Factors associated with emotional and behavioral outcomes in adolescents with multiple sclerosis. Multiple Sclerosis Journal, 18 (8), 1169-1179.


15.   Fuentes A, Collins DL, Garcia D, Sled JG, Narayanan S, Banwell BL, Till C.  (2012)  Relationship between memory outcomes and normalized regional brain volumes in pediatric-onset multiple sclerosis patients.  Journal of International Neuropsychological Society, 18 (3): 471-480.


16.   Till C, Deotto A, Tipu V, Sled JG, Bethune A, Narayanan S, Arnold DL, Banwell B.  (2011)  White matter integrity and math performance in pediatric multiple sclerosis:  a diffusion tensor imaging study.  NeuroReport, 22 (18): 1005-1009.


17.   Bethune A, Tipu V, Sled JG, Narayanan S, Arnold DL, Mabbott D, Rockel C, Ghassemi R, Till C, Banwell B. (2011)  Diffusion tensor imaging and processing speed in children with multiple sclerosis. Journal of the Neurological Sciences, 309, 68-74.


18.    Till C, Broche-Aubert B, Ghassemi R, Arnold DL, Narayanan S, Collins L, Kerbat A, Desrocher, M, Sled, J, Banwell B. (2011) MRI correlates of cognitive impairment in children and adolescents with multiple sclerosis.  Neuropsychology, 25(3), 319-332.


19.   Till C, Christensen B, Green REA.  (2009)  Use of the Personality Assessment Inventory (PAI) with brain-injured individuals:  Do neurologically relevant items on the PAI impact clinical interpretation? Brain Injury, 23(7-8), 655-665.


20.   Till C, Collela B, Verwegen J, Green REA.  (2008)  Postrecovery cognitive decline in adults with traumatic brain injury.  Archives of Physical Rehabilitation and Medicine, 89(2), S25-S34.


21.   Till C, Koren G, Rovet J.  (2008) Workplace standards for exposure to neurotoxicants during pregnancy, Canadian Journal of Public Health, 99 (6), 472-474. 


22.   Till C, Nulman I, Koren G, Westall CA, Rovet J. (2005). Vision abnormalities in young children exposed prenatally to organic solvents.  Neurotoxicology, 26 (4), 599-613.


23.  Till C, Koren G, Rovet J, Westall CA. (2003). Assessment of visual functions following prenatal exposure to organic solvents.  Neurotoxicology, 24, 725-731. 


24.   Till C, Koren G, Rovet J. (2002). Agreement between prospective and retrospective reports of maternal exposure to chemicals during pregnancy.  Journal of Occupational and Environmental Medicine, 44 (8), 708-713. 


25.   Till C, Koren G, Rovet J.  (2001). Prenatal exposure to organic solvents and child neurobehavioral performance.  Neurotoxicology and Teratology, 23, 1-11. 

Affiliations

Adjunct Scientist, Research Institute, Neurosciences & Mental Health

Research Scientist, North York General Hospital

Service/Community Activities

Executive Committee, endMS Manitoba-Ontario Regional Training Program

Member of Canadian Children’s Environment and Health Researc

Awards

Doctoral Dissertation Award - 2005

APA Division 40 Blue Ribbon Award - 2009

Dean's Health Research Catalyst Award - 2010

Supervision

Currently available to supervise graduate students: Not Indicated

Currently taking on work-study students, Graduate Assistants or Volunteers: Yes

Available to supervise undergraduate thesis projects: Yes

Current Research

 Dr. Till's research interests are as follows:  children's environmental health, clinical neuropsychology, neurodegenerative disease, and cognitive rehabilitation.

Research Projects

Neurocognitive effects of demyelinating disease during development
Specific objectives of this program of research include examining: (a) brain-behaviour relations using longitudinal cognitive and MRI methods, (b) clinical and neural correlates of cognitive decline in individuals with demyelination, and (c) if changes in white matter integrity underlies intra-individual variability in neurocognition. Much of this work is conducted in a collaborative context with colleagues from neurology and radiology. Determining the underlying causes of decline in neurocognition associated with demyelinating disease is necessary for developing appropriate and effective rehabilitation programs to mediate these effects and improve quality of life.
Role: Principal Investigator
Amount funded: $220000
Year Funded: 2008
Duration: 2
Funded by: Other...
Other funding: MS Society of Canada

Structural and functional neuroimaging correlates of cognitive impairment in childhood-onset multiple sclerosis
This research is assessing the functional neuroanatomy of executive control networks in MS patients who experienced recurrent attacks on the CNS during a key period of development. This study will use distinct executive control tasks that have been associated with different neural networks to understand how the developing brain may adapt to progressive and diffuse injury. A secondary objective is to examine the resting state network in MS patients compared with a healthy control group.
Role: Principal Investigator
Amount funded: $105000
Year Funded: 2011
Duration: 3
Funded by: Other...
Other funding: Scottish Rite Charitable Foundation of Canada

The clinical-demographic, epidemiology, pathobiology and neuroimaging features of acute demyelination in Canadian children
My role on this project involves overseeing the neuropsychological assessments of 100 patients with demyelinating disease and 100 healthy controls recruited through this initiative and heading the research related to neurocognition and assessment of quality of life in this population
Role: Co-Principal Investigator
Amount funded: $4.653 M
Year Funded: 2009
Duration: 3
Funded by: Other...
Other funding: Multiple Sclerosis Scientific Research Foundation